med 6

3 months ago

Untitled

ABSTRACT Immune checkpoint inhibitors (ICI) have transformed the therapeutic landscape in oncology. However, ICI can induce uncommon life-threatening autoimmune T-cell-mediated myotoxicities, including myocarditis and myositis. The thymus plays a critical role in T cell maturation. Here we demonstrate that thymic alterations are associated with increased incidence and severity of ICI myotoxicities. First, using the international pharmacovigilance database VigiBase, the Assistance Publique Hôpitaux de Paris-Sorbonne University data warehouse (Paris, France) and a meta-analysi... más información

med 63 months ago

Untitled

ABSTRACT Experimental inhibition of the (pro)renin receptor [(P)RR] is a promising therapeutic strategy in different disease models ranging from cardiorenal to oncological entities. Here, we briefly review the direct protein-protein interaction partners of the (P)RR and the plethora of distinct diseases in which the (P)RR is involved. The first structural work on the (P)RR using AlphaFold, which was recently published by Ebihara et al., is the center of this mini-review since it can mechanistically link the protein-protein interaction level with the pathophysiological level.... más información

med 63 months ago

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edetates, 260 ethylcellulose, 278 ethylene glycol palmitostearate, 283 glycerin monostearate, 308 guar gum, 315 hydroxypropyl cellulose, 336 hypromellose, 346 invert sugar, 747 lecithin, 409 magnesium aluminum silicate, 418 mineral oil and lanolin alcohols, 476 monoethanolamine, 478 pectin, 507 polacrilin potassium, 532 poloxamer, 535 polyvinyl alcohol, 592 potassium alginate, 594 potassium chloride, 600 povidone, 611 propyl gallate, 619 propylene glycol, 624 propylene glycol alginate, 627 raffinose, 635 sodium acetate, 654 sodium alginate, 656 sodium borate, 669... más información

med 63 months ago

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Pyrrolidone, 633 2-Pyrrolidone, 633 Quammonium, 152 Quassin, 224 Quaternary ammonium compounds benzalkonium chloride, 61 benzethonium chloride, 64 cetrimide, 152 imidurea, 359 incompatibilities anionic emulsifying wax, 807 nonionic emulsifying wax, 815 talc, 768 Quaternium 18-hectorite, 319 (R)-(-)-2-Hydroxypropionic acid, 381 R-227, 321 Racementhol, 459 Racemic lactic acid, 381 Racemic menthol, 459–460 Raffinose, 635 D-Raffinose, 635 Raftiline, 362 Rape oil, 109 Rapeseed oil, 109 alternatives, olive oil, 109 erucic acid, 108–109 Rayon, 790 RC Plasticizer DBP, 234... más información

med 63 months ago

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Modified starch dusting powder, 734 Monestriol EN-A, 284 Monobasic potassium phosphate, 697 Monobasic sodium phosphate, 694, 696 anhydrous, 696 dihydrate, 696 monohydrate, 696 Monobutyl/monoethyl ester mix, of poly(methylvinyl ether/maleic acid), 561 Monocizer DBP, 234 Monoester with 1,2,3-propanetriol, 308 Monoethanolamine, 239, 478, 795 Monoethyl ester, of poly(methylvinyl ether/ maleic acid), 561 Monoethyl/monobutyl ester mix, of poly(methylvinyl ether/maleic acid), 561 Monogramming, tablet/capsule, shellac, 649 Monolan, 535 Monolein, 306 Monomuls 90-O18, 306 Mono-ol... más información

med 63 months ago

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2-Hydroxyethyl ester stearic acid, 284 Hydroxyethyl ether cellulose, 330 Hydroxyethyl methylcellulose, 334 b-Hydroxyethyl phenyl ether, 517 Hydroxyethyl starch, 330 b-Hydroxyethylamine, 478 Hydroxyethylcellulose, 330 Hydroxyethylcellulosum, 330 Hydroxyethyl-b-cyclodextrin, 219, 756 Hydroxyethylmethyl cellulose, 281, 333–334, 348, 464 Hydroxyethylmethylcellulose, 334 Hydroxy-2-ethyl-4-pyrone, 272 Hydroxylapatite, 100–101 Hydroxylpropyl starch, 344 Hydroxy-m-methoxybenzaldehyde, 798 3-Hydroxy-2-methyl-4H-pyran-4-one, 445 3-Hydroxy-1-methyl-4-isopropylbenzene, 780 N-(Hy... más información

med 63 months ago

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Ethanecarboxylic acid, 617 N,N'-1,2-Ethanediylbis[N- (carboxymethyl)glycine, dipotassium salt, 261 N,N-1,2-Ethanediylbis[N- (carboxymethyl)glycine], 260 tetrasodium salt, 262 trisodium salt, 262 Ethanoic acid, 6 Ethanol, 18–20 anhydrous, 19 dilute, 20 Ethanol (96%), 18 Ethanolamine, 478 Ethanolic acid, 6 Ethanolum (96 per centum), 18 1,2-Ethenedicarboxylic acid, 293 Ethenol, homopolymer, 592 Ethenyl-2-pyrrolidinone homopolymer, 214, 611 Ethiops iron, 364 Ethispheres, 132 Ethocel, 278 Ethol, 155 3-Ethoxy-4-hydroxybenzaldehyde, 276 Ethoxylated fatty acid esters, 585... más información

med 63 months ago

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Dichlorodifluoromethane, 176, 178, 322, 773 essential use status, 178 Montreal Protocol, 178 Dichlorotetrafluoroethane, 176, 322, 773 Montreal Protocol, 178 D-2,3-Didehydroerythro-hexono-1,4-lactone, 264 2,3-Didehydro-L-threo-hexono-1,4-lactone, 48 Dietary supplements calcium phosphate, tribasic, 100 linoleic acid, 414 Diethanolamine, 238, 479, 795 Diethyl phthalate, 235, 240, 249, 589 Diethylene glycol monopalmitostearate, 283– 284 Diethylene glycol palmitostearate, 284 Diethyleneglycoli monopalmitostearas, 284 Diethylis phthalas, 240 Diethylolamine, 238 1,1-Difluo... más información