kywods

3 months ago

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Empirical Formula and Molecular Weight Table I: Pharmacopeial specifications for peanut oil. Test JP 2001 PhEur 2005 USPNF 23 Identification + + + Solidification range 22–338C ~28C 26–338C Acid value 40.2 40.5 — Peroxide value — 45.0 — Unsaponifiable matter 41.5% 41.0% 41.5% Specific gravity 0.909–0.916 0.915 0.912–0.920 Alkaline impurities — + — Cottonseed oil — — + Rancidity — — + Iodine value 84–103 — 84–100 Saponification value 188–196 — 185–195 Refractive index at — — 1.462–4.464 408C Heavy metals — — 40.001% ... más información

kywods3 months ago

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Applications in Pharmaceutical Formulation or Technology Oleic acid is used as an emulsifying agent in foods and topical pharmaceutical formulations. It has also been used as a penetration enhancer in transdermal formulations,(1–14) to improve the bioavailability of poorly water-soluble drugs in tablet formulations,(15) and as part of a vehicle in soft gelatin capsules. Oleic acid has been reported to act as an ileal ’break’ that slows down the transit of luminal contents through the distal portion of the small bowel.(16) Table I: Pharmacopeial specifications for oleic acid. ... más información

kywods3 months ago

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Incompatibilities Generally compatible with most materials encountered in pharmaceutical formulations and food products. Method of Manufacture Nitrogen is obtained commercially, in large quantities, by the fractional distillation of liquefied air. Nitrogen 489 Safety Nitrogen is generally regarded as a nontoxic and nonirritant material. However, it is an asphyxiant and inhalation of large quantities is therefore hazardous. See also Section 18. Handling Precautions Handle in accordance with procedures for handling metal cylinders containing liquefied or compressed ga... más información

kywods3 months ago

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Applications in Pharmaceutical Formulation or Technology Light mineral oil is used in applications similar to those of mineral oil. It is used primarily as an excipient in topical pharmaceutical formulations where its emollient properties are exploited in ointment bases;(1–3) see Table I. It is also used in ophthalmic formulations.(4,5) Light mineral oil is additionally used in oil-in-water and polyethlylene glycol/gylcerol emul- sions;(6–9) as a solvent and lubricant in capsules and tablets; as a solvent and penetration enhancer in transdermal prepara- tions;(10) and as the ... más información

kywods3 months ago

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Typical Properties Antimicrobial activity: see Table III. Methylparaben exhibits antimicrobial activity of pH 4–8. Preservative efficacy decreases with increasing pH owing to the formation of the phenolate anion. Parabens are more active against yeasts and molds than against bacteria. They are also more active against Gram-positive bacteria than against Gram-negative bacteria. Table III: Minimum inhibitory concentrations (MICs) of methylparaben in aqueous solution.(4) Microorganism MIC (mg/mL) Aerobacter aerogenes ATCC 8308 2000 Aspergillus oryzae 600 Aspergil... más información

kywods3 months ago

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Comments Mannitol is an isomer of sorbitol, the difference between the two polyols occurring in the planar orientation of the OH group on the second carbon atom. Each isomer is characterized by its own individual set of properties, the most important difference being the response to moisture. Sorbitol is hygro- scopic, while mannitol resists moisture sorption, even at high relative humidities. Granular mannitol flows well and imparts improved flow properties to other materials. However, it usually cannot be used with concentrations of other materials exceeding 25% by weight. Rec... más información